Semaglutide vs. Tirzepatide for Weight Loss
Semaglutide vs. Tirzepatide. Or by brand names, Ozemic vs. Zepbound. When it come to weight loss, which is better? Well, here is some preliminary data that may point to an answer, in which they compared tirzepatide 10 and 15 mg with semaglutide 2.4 mg using an indirect treatment comparison.
What They Did:
Using SURMOUNT-1 and STEP 1 clinical trial data, mean percentage change in body weight from baseline and odds ratio (OR) of achieving 5% or greater weight loss were compared between tirzepatide 10 and 15 mg at week 72 and semaglutide 2.4 mg at week 68 using matching-adjusted indirect comparison of the efficacy estimand. Sensitivity analyses were completed using different methods, including the Bucher method, also using different estimands and/or time points.
What They Found:
There was a greater reductions in the % reduction in body weight with tirzepatide 10 and 15 mg versus semaglutide 2.4 mg. The difference was −4.67% at 10 mg of Tirzepatide and -5.92% with tirzepatide 15 mg dose. Also, more users achieved the “baseline of efficacy” of 5% weight loss with either dose of tirzepatide than semaglutide.
In my opinion, given all things being equal, this data would facor Tirzepatide, which has a dual mechanism of action [GLP-1 and GIP] vs. Semaglutide, which just works via GLP-1.
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